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Melike Lakadamyali

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Melike Lakadamyali
NationalityCypriot
Alma mater
Known forSuper-Resolution Microscopy
Single Molecule Biophysics
Scientific career
FieldsSuper-Resolution Microscopy
Single Molecule Biophysics
Institutions
Thesis Real-time Imaging of Viral Infection and Intracellular Transport in Live Cells  (2006)
Academic advisorsXiaowei Zhuang
Jeff Lichtman
WebsiteLakadamyali Lab

Melike Lakadamyali is a Cypriot physicist and a Full Professor of Physiology and of Cell and Developmental Biology (secondary) at the University of Pennsylvania in Philadelphia, renowned for her work in super-resolution microscopy and Single Molecule Biophysics. She is the Group Leader of the Lakadamyali Lab.[1]

Education

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From 1997 to 2001, Lakadamyali studied Physics at the University of Texas at Austin, USA. During the end of her university time, she gained some practical experience by working in the labs of Prof. Ken Shih and Prof. Josef A. Käs. From 2001 to 2006, she earned her Ph.D. in Physics at Harvard University, Cambridge, MA, USA, advised by Prof Xiaowei Zhuang,[2][3][4] focusing on the visualization of viral infection and intracellular transport in live cells.[5][6][7]

Career and research

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For her postgraduate work, Lakadamyali worked as a postdoctoral researcher under Prof Jeff Lichtman at the Center for Brain Science at Harvard University, MA, USA.[8]

Between 2010 and 2016, Lakadamyali was a Group Leader at ICFO - The Institute of Photonic Sciences in Barcelona, Spain, holding a Junior (2010-2015) and Senior (2015-2016) Group Leader position, respectively. Her group's superresolution microscopy study investigating the genome gained widespread attention. It reveals that our genome needs to be regularly packaged and links these packaging differences to stem cell state.[9][10][11]

In 2017, Lakadamyali returned to the United States to work as an Assistant Professor of Physiology and of Cell and Developmental Biology (secondary) at the University of Pennsylvania in Philadelphia.

In 2020, Lakadamyali was promoted to Associate Professor of Physiology and in 2024 she was promoted to Full Professor.

Lakadamyali's area of research is focused on examining biology at the level of its macromolecular machines. She aims to obtain a quantitative and biophysical comprehension of how these machines propel critical cell biological processes.[12][13][14] Hence, she is also involved in designing sophisticated microscopy techniques that strive to surmount the current limitations of existing methods, thereby enabling them to observe the macromolecular machinery of the cell in motion with superior spatiotemporal resolution.[15][16][17]

Lakadamyali is a well-known microscopist and biophysicist. Hence, she is frequently invited to speak at workshops[18][19] and conferences[20][21][22] in the field.

Since 2019, Lakadamyali has been a Reviewing Editor (Cell Biology) at eLife.[23]

Awards and honours

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References

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  1. ^ "Lakadamyali Lab". Lakadamyali Lab. Retrieved 2023-09-04.
  2. ^ "Curriculum Vitae: Melike Lakadamyali" (PDF). static1.squarespace.com. Retrieved 4 September 2023.
  3. ^ "Melike Lakadamyali". AcademiaNet. Retrieved 4 September 2023.
  4. ^ a b "Cell scientist to watch − Melike Lakadamyali | Journal of Cell Science | The Company of Biologists". Journals.biologists.com. 2017-05-15. Retrieved 2023-09-04.
  5. ^ Lakadamyali, Melike; Rust, Michael J.; Babcock, Hazen P.; Zhuang, Xiaowei (2003-08-05). "Visualizing infection of individual influenza viruses". Proceedings of the National Academy of Sciences. 100 (16): 9280–9285. Bibcode:2003PNAS..100.9280L. doi:10.1073/pnas.0832269100. ISSN 0027-8424. PMC 170909. PMID 12883000.
  6. ^ Rust, M. J.; Lakadamyali, M.; Brandenburg, B.; Zhuang, X. (2011-09-01). "Single-Particle Virus Tracking". Cold Spring Harbor Protocols. 2011 (9). Cshprotocols.cshlp.org: pdb.prot065631. doi:10.1101/pdb.prot065631. PMID 21880810. Retrieved 2023-09-04.
  7. ^ Rust, M. J.; Lakadamyali, M.; Brandenburg, B.; Zhuang, X. (2011-09-01). "Single-Virus Tracking in Live Cells". Cold Spring Harbor Protocols. 2011 (9). Cshprotocols.cshlp.org: pdb.top065623. doi:10.1101/pdb.top065623. PMID 21880811. Retrieved 2023-09-04.
  8. ^ Lakadamyali, M.; Babcock, H.; Bates, M.; Zhuang, X.; Lichtman, J. (2012-01-24). "3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing | PLOS ONE". PLOS ONE. 7 (1). Journals.plos.org: e30826. doi:10.1371/journal.pone.0030826. PMC 3265519. PMID 22292051.
  9. ^ Ricci, Maria Aurelia; Manzo, Carlo; García-Parajo, María Filomena; Lakadamyali, Melike; Pia Cosma, Maria (12 March 2015). "Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo". Cell. 160 (6): 1145–1158. doi:10.1016/j.cell.2015.01.054. hdl:10803/298724. PMID 25768910.
  10. ^ "Nucleosome clutches / Cell, March 12, 2015 (Vol. 160, Issue 6)". YouTube. Retrieved 2023-09-04.
  11. ^ "Centre for Genomic Regulation Website". Crg.eu. 2015-03-12. Retrieved 2023-09-04.
  12. ^ "Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches | Nucleic Acids Research | Oxford Academic". Academic.oup.com. Retrieved 2023-09-04.
  13. ^ Gómez-García, Pablo Aurelio; Portillo-Ledesma, Stephanie; Neguembor, Maria Victoria; Pesaresi, Martina; Oweis, Walaa; Rohrlich, Talia; Wieser, Stefan; Meshorer, Eran; Schlick, Tamar; Cosma, Maria Pia; Lakadamyali, Melike (2021). "Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation". Cell Reports. 34 (2). doi:10.1016/j.celrep.2020.108614. PMC 7842188. PMID 33440158.
  14. ^ Lakadamyali, Melike; Cosma, Maria Pia (2020). "Visualizing the genome in high resolution challenges our textbook understanding". Nature Methods. 17 (4): 371–379. doi:10.1038/s41592-020-0758-3. hdl:10230/43808. ISSN 1548-7105. PMID 32123395. S2CID 211729851.
  15. ^ "Melike Lakadamyali | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania". Med.upenn.edu. Retrieved 2023-09-04.
  16. ^ Bond, Charles; Santiago-Ruiz, Adriana N.; Tang, Qing; Lakadamyali, Melike (2022-01-20). "Technological advances in super-resolution microscopy to study cellular processes". Molecular Cell. 82 (2): 315–332. doi:10.1016/j.molcel.2021.12.022. PMC 8852216. PMID 35063099.
  17. ^ Hugelier, Siewert; Colosi, P.L.; Lakadamyali, Melike (2023-05-09). "Quantitative Single-Molecule Localization Microscopy". Annual Review of Biophysics. 52 (1): 139–160. doi:10.1146/annurev-biophys-111622-091212. ISSN 1936-122X. PMC 11268362. PMID 37159293.
  18. ^ "In situ structural biology: from cryo-EM to multi-scale modelling – Course and Conference Office". Embl.org. Retrieved 2023-09-04.
  19. ^ Home. "22nd Single Molecule Workshop". PicoQuant. Retrieved 2023-09-04.
  20. ^ "JCS2023: Imaging Cell Dynamics - The Company of Biologists". Biologists.com. Retrieved 2023-09-04.
  21. ^ "Seeing is Believing – Imaging the Molecular Processes of Life – Course and Conference Office". Embl.org. 2019-10-12. Retrieved 2023-09-04.
  22. ^ "Genome Organization & Nuclear Function 2022 | CSHL". meetings.cshl.edu. Retrieved 2023-09-04.
  23. ^ "Editors for Cell Biology". eLife. Retrieved 2023-09-04.
  24. ^ "EMBO Young Investigator Program". ICFO. Retrieved 2023-09-04.
  25. ^ "Physical Sciences and Engineering - List of Principal Investigators" (PDF). erc.europa.eu. Retrieved 4 September 2023.
  26. ^ "On the move: Motor-cargo and motor-microtubule interactions studied with quantitative, high spatio-temporal resolution microscopy in vivo". CORDIS. Retrieved 4 September 2023.
  27. ^ "ERC Starting Grant Awarded to Prof. Melike Lakadamyali". ICFO. Retrieved 2023-09-04.
  28. ^ Marx, Vivien (2017-08-01). "Melike Lakadamyali". Nature Methods. 14 (8): 755. doi:10.1038/nmeth.4369. ISSN 1548-7105.
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